Tangential flow filtration is a membrane separation technology commonly used in laboratories at present, belonging to the molecular weight level of filtration. It generally intercepts molecules in the range of 1-1000KD and can separate very small particles and soluble molecules in the solution. Tangential flow filtration is usually only suitable for separating molecules with size differences of 3-5 times or more, and is not suitable for separating molecules of similar sizes.

T01 stainless steel fixture

Can load 1-3 small 0.1m2 membrane packages for process development and small volume drug production

Size: 14 (long) × 11.5 (width) × 26 (high) cm

Weight: 5 kg

T05 stainless steel fixture

Can load 0.5-2.5m2 membrane packages, with a maximum capacity of 5m2 membrane packages (longer fixed screws need to be replaced)

Size: 28 (long) ×  9 (width) ×  25 (height) cm

Weight: 24 kg

Membranous capsule

The ultrafiltration membrane package has the characteristics of easy installation, easy cleaning, low working volume, and high interception efficiency. There are two types, T01 and T05, but all types have the same flow channel height and length, facilitating linear amplification of the process. The use of internal gaskets makes installation, cleaning, storage, replacement, and other operations more convenient and efficient. Low working volume and high interception efficiency maximize product yield.

Typical applications of membrane packaging:

• Concentration: Concentration and dialysis of biological macromolecules (recombinant proteins, monoclonal antibodies, viruses, etc.), desalination, buffer replacement

• Separation and purification

• Removing endotoxins

• Excluding macromolecules, etc

Filter material:

• Ultrafiltration membrane: hydrophilic polyether sulfone (PES)

Screen: Polypropylene (PP)

Gaskets: Silicone

Sealant: Silicone

Material characteristics: low adsorption of non-specific proteins, high product recovery rate, high throughput, and superior chemical compatibility

1. This system is suitable for the matching of fermentation tanks below 150L, used for the concentration and collection of fermentation cells, replacement of buffer solution, washing, or clarification and filtration after cell fragmentation;

2. This system can be linearly scaled up to industrialization.

1. Replacing conventional peristaltic pumps and silicone hoses with diaphragm pumps and 316L stainless steel pipeline components

2. Replacing conventional diaphragm pressure gauges with electronic pressure sensors

3. Sterile sample cup with stirring (10L or 20L)

4. Temperature sensor

5. Sample cup electronic scale weighing system, secondary peristaltic pump

6. Heat exchange device

7. Circulating flow meter

8. PLC automatic control system and touch screen